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. Author manuscript; available in PMC: 2020 Sep 23.
Published in final edited form as: Nat Genet. 2020 Mar 23;52(4):371–377. doi: 10.1038/s41588-020-0592-7

Fig. 2: Co-mutation plot from whole exome sequencing of brain metastasis patients.

Fig. 2:

Significantly recurrently mutated drivers identified by both MutSig2CV and dNdScv in BM-LUAD are shown, followed by significantly amplified or deleted drivers identified using GISTIC in BM-LUAD, along with additional known cancer drivers in lung adenocarcinoma. Genes highlighted in orange are candidate metastatic drivers identified by matched case-control comparison between BM-LUAD and TCGA-LUAD. Each column represents one brain metastasis. False discovery rates are controlled at 1%.