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. Author manuscript; available in PMC: 2021 Mar 18.
Published in final edited form as: J Am Chem Soc. 2020 Mar 4;142(11):4960–4964. doi: 10.1021/jacs.9b10377

Figure 1.

Figure 1.

Covalent docking to eIF4E Lys162. (a) Arylsulfonyl fluorides 1–7 prioritized by covalent docking. (b) eIF4E (1 μM) was treated with compound 2 (100 μM) with or without m7GTP (100 μM). At the indicated time points, eIF4E labeling by 2 was quantified by LC–MS. (c) Docked pose of compound 2 covalently bound to Lys162 (green) of eIF4E (docked to PDB ID 4DT6; pink side chains, gray surface).