Figure 1.
Colloidal lapatinib is stabilized by coaggregation with fulvestrant and polymeric surfactant. Colloidal drug aggregates were formulated with 50 μM total drug, and 0.01 mg mL−1 poly(D,L-lactide-co-2-methyl-2-carboxytrimethylene carbonate)-graft-poly(ethylene glycol) (PLAC-PEG) in phosphate buffered saline. A 1:3 mol ratio of lapatinib/fulvestrant was selected for its stability against (A) growth and (B) precipitation as measured by dynamic light scattering. (C) Fluorescence measurement (λex = 340 nm, λem = 450 nm) confirmed the presence of lapatinib in these co-colloids (n = 3, mean ± SD).