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. Author manuscript; available in PMC: 2020 Apr 6.
Published in final edited form as: ACS Chem Biol. 2019 Jun 25;14(7):1507–1514. doi: 10.1021/acschembio.9b00247

Figure 2.

Figure 2.

Lapatinib release from stable lapatinib-fulvestrant co-colloids is triggered by acidic conditions. Colloids were formulated with 12.5 μM lapatinib, 37.5 μM fulvestrant, and 0.01 mg mL−1 poly(D,L-lactide-co-2-methyl-2-carboxytrimethylene carbonate)-graft-poly(ethylene glycol) (PLAC-PEG) in PBS. (A) Lapatinib is released from the co-colloids with decreasing pH, whereas (B) fulvestrant is retained within the colloids. (C) Lapatinib release from co-colloids is triggered by acidification to pH 5.5 (colored arrows), whereas (D) fulvestrant release is unaffected (n ≥ 3, mean ± SD, one-way ANOVA with Tukey’s posthoc test, ns p > 0.05, ****p < 0.0001 compared to initial release at pH 7.4).