Table 1.
Baseline demographic, clinical and laboratory parameters stratified by plasma LRG1 level in ESRD patients.
| Total | 1st Tertile (n = 57) | 2nd Tertile (n = 56) | 3rd Tertile (n = 56) | p value | |
|---|---|---|---|---|---|
| LRG1 (μg/mL) | 67.7 (15.1) | 52.3 (8.0) | 67.8 (3.3) | 83.4 (11.0) | <0.001* |
| Age (years) | 62.6 (12.2) | 61.1 (12.2) | 61.6 (12.5) | 65.2 (11.5) | 0.159 |
| Dialysis vintage (years) | 5.3 (4.0) | 5.3 (3.8) | 5.7 (4.8) | 4.9 (3.5) | 0.593 |
| Male (%) | 42 | 40 | 39 | 46 | 0.714 |
| Diabetes (%) | 41 | 32 | 39 | 54 | 0.055 |
| WBC (x 1000/μL) | 6.3 (2.0) | 6.0 (1.8) | 6.3 (2.0) | 6.7 (2.2) | 0.193 |
| Hemoglobin (g/dL) | 10.4 (1.2) | 10.7 (0.9) | 10.5 (1.2) | 10 (1.4) | 0.013* |
| Albumin (g/dL) | 3.91 (0.42) | 3.99 (0.36) | 4.00 (0.36) | 3.75 (0.50) | 0.001* |
| BUN (mg/dL) | 84.3 (19.5) | 83.4 (14.5) | 89.1 (19.1) | 80.5 (23.4) | 0.061 |
| Creatinine (mg/dL) | 11.7 (2.6) | 11.9 (2.4) | 12.3 (2.6) | 10.8 (2.8) | 0.011* |
| Kt/V (Gotch) | 1.46 (0.18) | 1.50 (0.18) | 1.47 (0.18) | 1.42 (0.17) | 0.058 |
| nPCR (g/Kg) | 1.22 (0.64) | 1.29 (0.33) | 1.33 (0.38) | 1.03 (0.97) | 0.099 |
| Total cholesterol (mg/dL) | 141.9 (31.5) | 140.1(29.9) | 142.6 (32.7) | 143.0 (32.4) | 0.870 |
| Triglyceride (mg/dL) | 130.5 (78.1) | 130.9 (86.3) | 134.3 (71.3) | 126.0 (76.8) | 0.860 |
| Calcium (mg/dL) | 9.6 (0.8) | 9.8 (0.9) | 9.6 (0.7) | 9.4 (0.7) | 0.100 |
| Phosphate (mg/dL) | 4.9 (1.5) | 4.9 (1.6) | 5.2 (1.3) | 4.6 (1.6) | 0.122 |
| Intact PTH (pg/mL) | 355.8 (452.1) | 290.5 (326.9) | 381.0 (487.3) | 399.5 (524.6) | 0.403 |
| hsCRP (mg/dL) | 0.81 (1.46) | 0.31 (0.34) | 0.53 (0.86) | 1.59 (2.16) | <0.0001 |
| IL-6 (pg/mL) | 4.79 (3.65) | 3.54 (1.61) | 3.56 (2.62) | 6.62 (4.60) | <0.0001 |
| TNF-α (pg/mL) | 6.29 (1.85) | 6.43 (1.52) | 6.17 (1.93) | 6.27 (2.06) | 0.88 |
| CAD (%) | 22 | 14 | 25 | 27 | 0.209 |
| CHF (%) | 21 | 19 | 21 | 21 | 0.950 |
| MI (%) | 5 | 2 | 7 | 7 | 0.341 |
| PAOD (%) | 7 | 0 | 7 | 13 | 0.025* |
| Stroke (%) | 4 | 4 | 4 | 5 | 0.858 |
| CVD (%) | 27 | 16 | 29 | 37 | 0.033* |
Demographic and clinic data were compared across among LRG1 tertiles in 169 ESRD patients in the iESRD cohort. Continuous values are expressed as means (SD). nPCR: normalized protein catabolic rate; CAD: coronary artery disease; CHF: congestive heart failure; MI: myocardial infarction; PAOD: peripheral artery occlusive disease; CVD: cardiovascular disease. *p value < 0.05.