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. 2020 Apr 6;10:5986. doi: 10.1038/s41598-020-62663-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-HCV and anti-HBV activity of the extracted pigments. (A) The viral clearance percentages in HCV- and HBV-infected peripheral blood mononuclear cells (PBMCs) after treatment with pigments or standard viral drugs (sofosbuvir and lamivudine for HCV and HBV, respectively) at their safe doses (these percentages were estimated elative to those in untreated infected PBMCs). (B) IC₅₀ values of pigments and standard viral drugs for inhibition of HCV-NS5B polymerase and DNA-dependent HBV polymerase. All data are expressed as the mean ± SE with significance (unpaired t-test analysis) at p-value < 0.05*, <0.005**, <0.0005***.