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. 2020 Apr 6;10:5971. doi: 10.1038/s41598-020-62912-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinicopathological relevance of CXXC5 expressions in breast cancer patients. (a) CXXC5 expression in breast cancer (BC) as compared to normal breast tissue from METABRIC. (b) CXXC5 expression in ER-negative versus ER-positive breast cancer patients from METABRIC. (c) CXXC5 expression in different molecular subtypes of tumors of breast cancer patients from METABRIC. (d) Pearson correlation analysis between mRNA expressions of CXXC5 and ESR1 (ERα) in patients from METABRIC. (e) Pearson correlation analysis between mRNA expression of CXXC5 and ERα protein level in breast cancer patients from TCGA. (f) Kaplan Meier survival analysis of basal breast cancer patients based on CXXC5 expression separated from the median.