Figure 6.

Effects of experimental noise on ensemble reweighting. (A) Decision plot and (B) RMSD probability distributions after reweighting with noise added to target data are shown. In both panels, data from reweighting performed without noise added to the target data are shown in black, while orange and teal represent results from reweighting with added noise of increasing magnitude. RMSD distributions are compared after reweighting with W_app = 1.64 kJ mol⁻¹, indicated by the dashed line in (A). The unbiased RMSD distribution is shown in cyan.