Table 3.

Association of clinical characteristics with absolute decline in hemoglobin within 7 days after biopsy, before and after multivariable adjustment

Characteristic	Univariable models			Multivariable modela			Model using stepwise selection procedureb
	β coefficient	95% CI	P value	β coefficient	95% CI	P value	β coefficient	95% CI	P value
Age, per 10-yr increase	0.02	−0.02 to 0.05	0.44	0.00	−0.04 to 0.04	0.89	–	–	–
Female sex	0.07	−0.06 to 0.20	0.29	0.18	0.04 to 0.32	0.01	0.17	0.04 to 0.31	0.01
Diabetes	0.09	−0.08 to 0.26	0.28	0.10	−0.08 to 0.27	0.29	–	–	–
Systolic blood pressure, per 10 mm Hg increase	−0.02	−0.05 to 0.02	0.31	−0.03	−0.04 to 0.04	0.89	–	–	–
eGFR <30 ml/min per 1.73 m2	0.16	0.03 to 0.30	0.02	0.32	0.14 to 0.49	<0.01	0.36	0.20 to 0.51	<0.01
Platelet count <150 K/μl	−0.05	−0.27 to 0.17	0.66	0.00	−0.22 to 0.22	0.97	–	–	–
INR ≥1.1	0.00	−0.13 to 0.14	0.96	0.03	−0.12 to 0.19	0.70	–	–	–
Worsening eGFR as indication for biopsy	0.06	−0.07 to 0.19	0.37	0.07	−0.08 to 0.22	0.35	–	–	–
Urgent inpatient biopsy	0.02	−0.14 to 0.18	0.81	0.01	−0.18 to 0.19	0.94	–	–	–
Baseline Hgb, per 1 g/dl increase	0.03	0.00 to 0.06	0.03	0.09	0.05 to 0.13	<0.01	0.08	0.04 to 0.11	<0.01

CI, confidence interval; eGFR, estimated glomerular filtration rate; Hgb, hemoglobin; INR, international normalized ratio.

^aAll clinical characteristics of interest, shown in the table, were included in the model.

^bAll clinical characteristics of interest, shown in the table, were included in the initial model and an automated stepwise selection procedure was then used to choose predictors.