Table 4.
Association of 9p21 SNP genotypes with the high-level IFNA21 group (>15.6 pg/ml).
| S. No. | SNP ID | Homozygote for normal allele (Reference value 1) | Homozygote for variant allele (OR 95% CI) | p value | Heterozygote (OR 95% CI) | p-value |
|---|---|---|---|---|---|---|
| 1 | rs1004638 | TT (1) | AA-0.546 (0.279–1.068) | 0.077 | AT-0.609 (0.367–1.012) | 0.056 |
| 2 | rs10116277 | TT (1) | GG-0.514 (0.269–0.983) | 0.044 | GT-0.636 (0.389–1.041) | 0.072 |
| 3 | rs1011970 | GG (1) | TT-1.152 (0.516–2.572) | 0.731 | TG-1.027 (0.642–1.643) | 0.913 |
| 4 | rs1063192 | AA (1) | GG-0.708 (0.267–1.880) | 0.489 | GA-0.714 (0.448–1.136) | 0.155 |
| 5 | rs10757272 | CC (1) | TT-2.000 (1.029–3.887) | 0.041 | CT-1.179 (0.620–2.242) | 0.616 |
| 6 | rs10757274 | AA (1) | GG-2.263 (1.212–4.224) | 0.010 | AG-1.093 (0.631–1.893) | 0.752 |
| 7 | rs10757283 | CC (1) | TT-2.217 (1.110–4.427) | 0.024 | CT-0.794 (0.470–1.341) | 0.388 |
| 8 | rs10811661 | TT (1) | CC-0.373 (0.087–1.599) | 0.184 | CT-0.898 (0.543–1.483) | 0.673 |
| 9 | rs1333040 | TT (1) | CC-0.631 (0.316–1.257) | 0.190 | CT-0.768 (0.477–1.236) | 0.276 |
| 10 | rs1333042 | GG (1) | AA-0.694 (0.344–1.404) | 0.310 | AG-0.625 (0.387–1.009) | 0.055 |
| 11 | rs1333045 | TT (1) | CC-2.526 (1.339–4.768) | 0.004 | CT-1.292 (0.741–2.252) | 0.366 |
| 12 | rs1333048 | AA (1) | CC-1.951 (1.022–3.723) | 0.043 | CA-0.951 (0.539–1.679) | 0.862 |
| 13 | rs1333049 | GG (1) | CC-2.186 (1.166–4.098) | 0.015 | CG-1.233 (0.715–2.126) | 0.45 |
| 14 | rs16905599 | GG (1) | AA-1.028(0.438–2.412) | 0.950 | AG-1.115 (0.689–1.805) | 0.656 |
| 15 | rs2383206 | AA (1) | GG-1.423 (0.759–2.668) | 0.271 | AG-0.903 (0.496–1.646) | 0.740 |
| 16 | rs2383207 | GG (1) | AA-0.726 (0.351–1.500) | 0.387 | AG-0.575 (0.356–0.928) | 0.023 |
| 17 | rs2383208 | AA (1) | GG-0.306 (0.075–1.255) | 0.100 | GA-0.894 (0.548–1.457) | 0.652 |
| 18 | rs2811712 | AA (1) | GG-0.901 (0.197–4.118) | 0.893 | AG-1.156 (0.692–1.931) | 0.580 |
| 19 | rs4977574 | AA (1) | GG-2.003 (1.067–3.763) | 0.031 | GA-0.963 (0.557–1.666) | 0.893 |
| 20 | rs4977756 | AA (1) | GG-0.587 (0.233–1.479) | 0.258 | GA-0.807 (0.503–1.295) | 0.374 |
| 21 | rs564398 | TT (1) | CC-1.137 (0.460–2.812) | 0.781 | CT-0.765 (0.472–1.239) | 0.276 |
| 22 | rs615552 | TT (1) | CC-0.787 (0.332–1.867) | 0.587 | CT-0.679 (0.424–1.086) | 0.106 |
| 23 | rs6475606 | TT (1) | CC-0.665 (0.339–1.305) | 0.236 | CT-0.679 (0.418–1.103) | 0.118 |
| 24 | rs7023329 | AA (1) | GG-1.250 (0.502–3.114) | 0.632 | GA-1.057 (0.664–1.680) | 0.816 |
| 25 | rs7865618 | AA (1) | GG-0.808 (0.373–1.748) | 0.588 | GA-0.720 (0.443–1.169) | 0.184 |
| 26 | rs9632884 | CC (1) | GG-0.576 (0.269–1.236) | 0.157 | GC-0.770 (0.481–1.233) | 0.277 |
The wild-type homozygote was taken as the normal/standard genotype with reference odds ratio value 1.
SNP IDs marked in bold show significant risk association for the variant allele homozygote.