Figure 1.

Clinical course of patients treated with eculizumab. Shown is the treatment regimen and clinical response for patient 1 (a) and patient 2 (b). Therapy for both patients included pulse methylprednisolone (blue arrows and blue rectangle), prednisone (black line), rituximab (green arrows), and eculizumab (gray arrows). Patient 1 also received low-dose oral cyclophosphamide (orange rectangle). The second rituximab infusion in patient 1 was slightly delayed, but flow cytometry confirmed that the patient had complete B-cell depletion immediately before this dose.