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. 2020 Mar 31;11:497. doi: 10.3389/fmicb.2020.00497

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Copyright © 2020 Luo, Yue, Yu, Ren, Zhang, Ren, Wang and Dou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Obacunone ameliorated body weight loss, bloody diarrhea, and colon shortening in IBD model mice. (A) Body weight was recorded after DSS induction of colitis. Data were plotted as a percentage of basal body weight. (B) The occurrence of bloody diarrhea. Data were plotted as the percentage of the total number of mice that had bloody diarrhea at different time points of DSS treatment. Macroscopic observation (C) and assessment of colon shortening (D) at the end of the study. Data were expressed as the mean ± SD (n = 6 mice per group). *p < 0.05, **p < 0.01, ***p < 0.001 vs. the DSS-treated group; ^###p < 0.001 vs. the control group.