Figure 8.

Select functional GO pathways skewed in non-phagocytic macrophages. Analysis of gene enrichment for biological processes and KEGG pathway was performed on the differential up- and down-regulated gene clusters (A). A search for GO pathways was performed to examine skewed functions comparing PKH2^hi and PKH2^lo macrophages in terms of tissue repair and fibrosis (B), phagocytic activity (C), bioenergetics (D), and mitochondrial dynamics (E). Data presented are differentially expressed (twofold change) genes from each GO term category with q ≤ 0.05.