TABLE 2.

Studies in the last 5 years using injectable hydrogels combined with cells for treating myocardial infarction.

Biomaterial	Type of cells	Animal model	Type of MI model/Processing time point after successful MI model	End-point after treatment	Injection site	Results compared to control	References
HA	Endothelial progenitor cell	Rats	Immediate acute myocardial infarction model	1/4 weeks	Myocardium	Minimize postischemic remodeling	Gaffey et al., 2015, 2019
FA	iPS	Mice	Immediate acute myocardial infarction model	1, 2, 4 weeks	Myocardium	Improved the retention and survival of iPS; less adverse heart remodeling and stimulation of neovascularization	Li H. et al., 2018
Chitosan	MSCs	Rats	1 weeks acute myocardial infarction model	24 h	Myocardium	Increased graft size and cell retention, promoted MSCs to differentiate into cardiomyocytes and increased the effects of MSCs on neovas-culature formation	Xu et al., 2017

HA, hyaluronic acid; FA, folic acid; iPS, induced pluripotent stem cells; MSCs, mesenchymal stem cells.