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. 2020 Mar 31;10:363. doi: 10.3389/fonc.2020.00363

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Copyright © 2020 Lan, Yao, Sun, Li, Liu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional domains of hnRNPA1 and SNHG6 could target the 3′UTR of the pyruvate kinase M (PKM) mRNA. (A) The first RNA recognitional motif (RRM) of hnRNPA1 began from the amino acid at position 16 and ended at the amino acid at position 85, while the second RRM of hnRNPA1 began from the amino acid at position 107 and ended at the amino acid at position 176. (B) miR-4755-5p was found to be homologous to SNHG6. (C) PKM was found to be the target gene of miR-4755-5p. (D) Schematic model of SNHG6-mediated aerobic glycolysis which proceeded through the splicing of PKM1/2 as a result of its interaction with the hnRNPA1 complex.