FIGURE 8.

Flavazolicines. (A) Comparison of biosynthetic gene clusters encoding a putative new group of LAPs found in Flavobacteria and Gammaproteobacteria genomes. Predicted functions of the Encoded proteins are listed below. (B) Comparison of precursor peptides of flavazolicins. Conserved core sequences containing cyclizable residues are shown with red background. The precursor peptide sequence of cyanobactins patellins 2 and 3 (truE1 gene product) is shown for comparison on the gray background. Functional parts of the peptide including leader (yellow), two cores (red), and recognition sequences of peptidases (RS1 and RS2) are shown (Gu et al., 2018). (C) Sequences of cassette-containing precursor peptides of flavazolicins showing the conserved positions in two leader sequences. Conserved positions are shown with green dashed lines, synonymous substitutions with yellow dashed lines. (D) A possible scenario in the evolution of cassette-containing peptides. See main text for the explanations.