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Key reaction fluxes of the network, in the first (gray boxes, top row) and second (gray boxes, bottom row) phases of metabolism. A. Fluxes of ATP generation and consumption, and GTP consumption toward protein synthesis. B. Fluxes of glycolysis and lactate and acetate metabolism. Fluxes are normalized to the first-phase glucose uptake rate. For PEP and pyruvate, accumulation (normalized to glucose uptake) is also shown.
