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Effect of group knockouts on system. A. Change in CAT productivity when one (diagonal) or two (off-diagonal) reaction groups are turned off. B. Change in system state (only species for which data exist) when one (diagonal) or two (off-diagonal) reaction groups are turned off. Total-order effect for each group calculated as the sum of first-order effect and all pairwise effects. Larger and darker circles represent greater effects.
