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. 2020 Mar 31;11:250. doi: 10.3389/fgene.2020.00250

FIGURE 4.

FIGURE 4

Inhibition of NEAT1 suppresses activate cGAS-STING signaling and inhibits CXCL10, CCL5, and IFNβ expression. (A,B) mRNA expression of CXCL10, CCL5, and IFNβ expression was detected in A549 cells and SK-MES-1 cells when transfected with the specific shRNA of NEAT1 by using RT-qPCR. (C,D) mRNA expression of CXCL10, CCL5, and IFNβ expression was detected by using RT-qPCR. (E) Protein level of cGAS-STING signaling-related molecules was detected in A549 cells and SK-MES-1 cells when silencing NEAT1 by using Western blot. The histogram indicated the quantification of the Western blot signals. (F) Protein level of cGAS-STING signaling-related molecules was detected in M109 cell lines and tumors when silencing NEAT1 by using Western blot. The histogram indicated the quantification of the Western blot signals. **p < 0.01, ***p < 0.001. Data are expressed as the mean ± SD.