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. 2020 Mar 31;11:250. doi: 10.3389/fgene.2020.00250

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Copyright © 2020 Ma, Lei, Ding, Luo, Xie and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nuclear paraspeckle assembly transcript 1 exhibited oncogenic effect at least partly dependent on DNMT1. (A,B) The proliferation of A549 cells and SK-MES-1 cells was analyzed after transfection with the specific shRNA for NEAT1 in the presence of DNMT1 inhibitor or not for 24, 48, 72, and 96 h by using MTT, respectively. (C,D) The cell migration and invasion of A549 cells and SK-MES-1 cells were analyzed after transfection with the specific shRNA for NEAT1 in the presence of DNMT1 inhibitor or not, respectively. (E,F) mRNA expression of P53, cGAS, and STING was detected in A549 cells and SK-MES-1 cells after transfection with the specific shRNA for NEAT1 in the presence of DNMT1 inhibitor or not, respectively, by using RT-qPCR. **p < 0.01, ***p < 0.001. Data are expressed as the mean ± SD.