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. 2020 Mar 31;8:225. doi: 10.3389/fchem.2020.00225

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Copyright © 2020 Huang, Chen, Zhu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of in vivo exposures. (A) Changes in tumor weight following treatment. (B) Change in tumor-volume curves of 4T1 tumor bearing mice after treatments. (C) Body weight of 4T1 tumor-bearing mice as recorded every 2 days following treatment. (D) Pharmacokinetic behavior of QM and CQM in mice following i.v. administration at doses of 5 mg/kg of MSNs. Data are presented as mean ± SD (n = 3). (E) Quantitative analysis of QM biodistribution in tissues and tumors of tumor-bearing mice injected with QM or CQM at MSNs dose of 5 mg/kg, respectively. (F) Representative Ki-67 stained tumor slice images of mice following treatment. Scale bars: 100 nm. Significant differences among groups as calculated using the Student's t-test. ***P < 0.005.