Fig. 4.

Dissociated abnormalities in large-scale brain networks between acute and remitted patients with bipolar disorder (BD). Acute-state-related hypoconnectivity within the AN and DMN and AN–DMN hyperconnectivity might reflect dysregulated emotional processing and cognition in BD patients during the active phase. However, there is also remitted-state-related hyperconnectivity within the DMN and between the AN and DMN, which may underlie abnormal cognitive regulation during remission. Both findings indicate that abnormal emotional processing is a state-related impairment that is evident in acutely ill patients but normalized with remission. Cognitive dysregulation is a trait-related impairment in BD patients that is common in both acute and remission states. BDA, BD in acute state; BDR, BD in remission; HC, healthy control.