Table 3.
Results of meta-analysis of altered DMN resting-state functional connectivity in BD patients compared with HCs.
| Seed network | Seed region | Effect network | Effect region | MNI coordinate | SDM-Z | P value | Voxels |
|---|---|---|---|---|---|---|---|
| DMN | ACC, PCC, MPFC, MTG, VLPFC, HIPP, VSS, caudate, cerebellum, precuneus | ||||||
| BDA vs. HC (datasets=14) | |||||||
| BDA > HC | FPN | Left DLPFC | −34, 38, 12 | 1.659 | 0.0002 | 408 | |
| DAN | Right dorsal-anterior precuneus | 8, −52, 72 | 2.001 | <0.0001 | 435 | ||
| BDA < HC | DMN | Right PCC/precuneus | 4, −54, 28 | −1.705 | 0.0002 | 188 | |
| DMN | Right DMPFC/SFG | 16, 62, 16 | −2.259 | 0.0003 | 545 | ||
| BDR vs. HC (datasets=8) | |||||||
| BDR>HC | DMN | Left PCC/precuneus | −10, −54, 38 | 2.585 | 0.0002 | 885 | |
| BDA vs. BDR | |||||||
| BDA > BDR | DAN | Right dorsal-anterior precuneus | 8, −52, 72 | 1.042 | <0.0001 | 385 | |
| BDA < BDR | DMN | Left PCC/precuneus | −10, −54, 38 | −2.473 | <0.0001 | 1428 | |
Abbreviations: bipolar disorder (BD), BD in remission (BDR), BD in acute state (BDA), healthy controls (HC), default-mode network (DMN), affective network (AN), frontoparietal network (FPN), somatomotor network (SMN), dorsal attention network (DAN), superior frontal gyrus (SFG), orbitofrontal cortex (OFC), medial prefrontal cortex (MPFC), dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), rostral anterior cingulate cortex (rACC), ventromedial prefrontal cortex (VMPFC), ventrolateral prefrontal cortex (VLPFC), anterior cingulate cortex (ACC), subgenual anterior cingulate cortex (sgACC), posterior cingulate cortex (PCC), nucleus accumbens (NAcc), hippocampus (HIPP), parahippocampus (Para-HIPP), superior temporal gyrus (STG), middle temporal gyrus (MTG), supplementary motor area (SMA).