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. Author manuscript; available in PMC: 2020 Apr 6.
Published in final edited form as: Annu Rev Immunol. 2019 Jan 23;37:349–375. doi: 10.1146/annurev-immunol-042718-041356

Figure 3.

Figure 3

OASes and ADARs. (a) Domain architectures and structures of human OAS1–3 and OASL. The structure of OAS1 in complex with dsRNA (PDB: 4IG8). The OAS1 structure is also superposed onto cGAS in complex with dsDNA (PDB: 6CT9) and OAS3 (first pseudo-NTase domain) in complex with dsRNA (PDB: 4S3N). The second UbL domain of OASL (green, PDB: 1WH3) is superposed onto the structure of Ub (dark blue) on the right. (b) Schematic of adenosine-to-inosine modification and domain architectures of human ADAR1–3. The structure of dsRBD1–2 of ADAR2 in complex with dsRNA (PDB: 2L3J). Structures of ADAR1 ZBD1 in complex with dsRNA in the Z-form (PDB: 2GXB) and the deaminase domain of ADAR2 (PDB: 5HP2) are also shown on the right. Abbreviations: ADAR, adenosine deaminase acting on RNA 1; dsRBD, dsRNA-binding domain; NTase, nucleotidyl transferase; OAS, oligoadenylate synthase; PDB, Protein Data Bank; Ub, ubiquitin; ZBD, Z-DNA-binding domain.