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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Curr Opin Immunol. 2020 Jan 16;62:91–98. doi: 10.1016/j.coi.2019.12.006

Figure 2: Gene expression analysis of genes whose expression is upregulated in the Botryllus cHSC and endostyle as compared to the expression of their homologues (based on sequence similarities) in the mouse hematopoiesis lineages.

Figure 2:

a. Multi-gene analysis (235 genes) using Geneset Activity Analysis of the genes significantly upregulated by the candidate HSCs cell population of B. schlosseri. The enriched populations are HSCs and the myeloid lineage (adopted from Ref. [22]). b. Multi-gene analysis using Geneset Activity Analysis (https://gexc.riken) of top 200 genes significantly upregulated in the B. schlosseri endostyle associated with the blood system, on a mouse hematopoiesis model including the bone marrow (BM) stromal cells. This analysis revealed significant activity between the mouse bone marrow stromal cells and the B. schlosseri endostyle (adopted from Ref. [22]). c. Expression of C3 (complement component 3) gene, as determined by microarray analysis, in 39 different mouse hematopoietic populations. The C3 expresses in the phagocytic myeloid lineage, highest levels of the gene expression activity are detected in the granulocytes (Gra) and monocytes (Mono), and some activity is detected in their common progenitor (GMP).