Table 10.
Mean of the biochemical parameters of group rats which received polyherbal formulation or control after 45 days in the subchronic oral toxicity study.
| Unit | Control | Dose | |||
|---|---|---|---|---|---|
| 252 mg/kg | 1,008 mg/kg | 4,032 mg/kg | |||
| Male (n = 5) | |||||
| Urea | mg/dL | 45.25 ± 4.57 | 46.06 ± 4.34 | 37.60 ± 5.52 | 48.80 ± 4.30 |
| Creatinine | mg/dL | 0.46 ± 0.05 | 0.44 ± 0.05 | 0.40 ± 0.00 | 0.48 ± 0.04 |
| Total protein | mg/dL | 5.82 ± 0.49 | 5.02 ± 0.85 | 5.42 ± 0.36 | 7.66 ± 0.64∗ |
| Albumin | g/dL | 3.52 ± 0.23 | 3.86 ± 0.40 | 3.40 ± 0.37 | 3.62 ± 0.13 |
| Globulin | g/dL | 2.30 ± 0.50 | 1.16 ± 0.56∗ | 2.02 ± 0.08 | 4.04 ± 0.63∗ |
| AST (GOT) | U/L | 174.58 ± 27.79 | 225.70 ± 28.96∗ | 156.96 ± 24.41 | 190.78 ± 322.45 |
| ALT (ALT) | U/L | 110.48 ± 11.73 | 146.14 ± 37.14 | 91.52 ± 16.75 | 112.80 ± 27.45 |
|
| |||||
| Female (n = 5) | |||||
| Urea | Mg/dL | 40.94 ± 9.04 | 47.36 ± 4.26 | 37.34 ± 5.34∗ | 48.30 ± 2.76 |
| Creatinine | Mg/dL | 0.54 ± 0.09 | 0.52 ± 0.13 | 0.42 ± 0.08 | 0.52 ± 0.04 |
| Total protein | Mg/dL | 6.32 ± 0.36 | 5.92 ± 0.43 | 5.64 ± 0.23 | 8.56 ± 0.67∗ |
| Albumin | g/dL | 4.04 ± 0.31 | 4.5 ± 0.42 | 3.86 ± 0.52 | 4.04 ± 0.23 |
| Globulin | g/dL | 2.32 ± 0.30 | 1.42 ± 0.50∗ | 1.72 ± 0.34 | 4.52 ± 0.57∗ |
| AST (GOT) | U/L | 148.92 ± 21.12 | 219.04 ± 63.70 | 196.70 ± 65.45 | 175.06 ± 39.34 |
| ALT (ALT) | U/L | 85.72 ± 16.17 | 144.30 ± 54.59 | 115.20 ± 42.03 | 100.30 ± 29.62 |
∗ p < 0.05, the significant difference compared to the control group using the one-way ANOVA continued by Tukey's multiple comparison test.