Table 4.

Pathways predictive of poor survival and significantly altered in the poor survival cluster in both the original and the validation datasets.

Pathway	Log rank test (validation data)
	p-value	p-value adj.
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	1.35E-06	0.000142
SHC1 events in EGFR signaling	6.43E-05	0.003378
GRB2 events in EGFR signaling	0.000209	0.007326
Activation of NOXA and translocation to mitochondria	0.000852	0.016340
EGFR Transactivation by Gastrin	0.000896	0.016340
PI5P Regulates TP53 Acetylation	0.000933	0.016340
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	0.001340	0.020119
SUMOylation of transcription factors	0.001583	0.020241
TP53 Regulates Transcription of Death Receptors and Ligands	0.001734	0.020241
Activation of PUMA and translocation to mitochondria	0.002852	0.029962
Regulation of TP53 Activity through Methylation	0.003273	0.031153
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.003558	0.031153
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.004291	0.032203
Regulation of PTEN gene transcription	0.004170	0.032203