Figure. Associations of Early Management Bundle for Severe Sepsis/Septic Shock (SEP-1) and Components With Risk of Mortality and Vasopressor Days in Cohorts With Community-Onset and Hospital-Onset Sepsis.

Community-onset sepsis was defined by occurrence of time 0 of sepsis in the emergency department; hospital-onset, time 0 in an inpatient unit. Patients with signs of infection or clinical instability in the emergency department who did not meet the criteria for sepsis until arrival in an inpatient unit were counted as having hospital-onset sepsis. Vasopressor days indicates the requirement of blood pressure support with a vasopressor medication in the 10 days after time 0.