Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 31;11:299. doi: 10.3389/fgene.2020.00299

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Zhu, Liu, Xu, Liu, Xie, Sham, Sha and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Heart defects was successfully rescued in Mdgcr8, but not in MZdgcr8. (A) The cardiac progenitor cells failed to migrate to the middle-line at prim-16 stage (32 hpf) in Mdgcr8 and MZdgcr8 (red arrows). (B) After miR430 rescue, cardiogenesis appeared normal including structure of atrium and ventricle. (C) MZdgcr8 failed to be rescued by mir430, exhibiting hydropericardium phenotype. (D,E) Heart-rate results indicated that the heart defects were completely rescued in Mdgcr8, but only partially in MZdgcr8, and MZdgcr8 heart rate gradually decreased at 4 days. **p < 0.01, ***p < 0.001, and ****p < 0.0001.