Table 1.
The effects of microRNAs on PD-1/PD-L1 in different cancers
| microRNAs | function | cancer | mechanism | reference |
|---|---|---|---|---|
| miR-155 | activation of the immune system | lymphoma | promoting PD-L1 | 45 |
| miR-34 | inducing a tumor immune response | Non-small cell lung cancer | inhibiting PD-L1 | 47 |
| miR-33a | regulating the expression of immune markers | lung adenocarcinoma | suppressing PD-1/PD-L1 | 50 |
| miR-21 | regulating the immune response | gastric cancer | suppressing PD-1 | 53-54 |
| miR-146a | regulating immune cells | melanoma | promoting PD-L1 | 68 |
| miR-873 | regulating the expression of immune markers | breast cancer | inhibiting PD-L1 | 55 |