Figure EV2. OVCAR xenograft tumor model mimics human HGSC .

• A
  Representative images of tumors in OVCAR4 xenograft mice, mimicking the development of HGSC in patients: accumulation of ascites in the peritoneal cavity, widely disseminated metastatic foci, and multiple nodules located in the omentum and peritoneal membrane.
• B–D
  Histological assessment of proliferation by Ki67 and apoptosis by TUNEL (B) and corresponding quantification of Ki67⁺ (C) and TUNEL⁺ (D) OVCAR4 in xenograft tumors of mock and carboplatin‐treated mice. N = 5 mice/group. Scale: 200 µm. Carboplatin treatment significantly induced apoptosis but had no major effect on proliferation.

Data information: In (C, D), data are presented as mean (SD). *P < 0.05. Exact P‐values are provided in Appendix Table S10, Mann–Whitney U‐test.