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. 2020 Mar 18;12(4):e09271. doi: 10.15252/emmm.201809271

Figure 7. Endothelium‐specific deletion of Rbpj improves glucose tolerance in obese mice.

Figure 7

  • A
    Schematic illustration of feeding and recombination protocol.
  • B
    Blood glucose levels for glucose tolerance test (GTT) of control (n = 4) or Rbpj iΔEC (n = 5) mice kept on high‐fat diet (HFD). Data represent unpaired t‐test, mean ± SEM.
  • C
    Quantification of area under curve (AUC) for GTT in (B). Data represent mean ± SEM, unpaired t‐test.
  • D
    Blood glucose levels for insulin tolerance test (ITT) of control (n = 4) or Rbpj iΔEC (n = 3) mice kept on HFD. Data represent unpaired t‐test, mean ± SEM.
  • E
    Quantification of AUC for ITT in (D). Data represent mean ± SEM, unpaired t‐test.
  • F
    HbA1c levels of control (n = 4) or Rbpj iΔEC (n = 6) mice kept on HFD 7 weeks after recombination. Data represent mean ± SEM, unpaired t‐test.
  • G
    Schematic illustration of 2‐DG uptake assay protocol for control and Rbpj iΔEC mice on HFD.
  • H
    Blood glucose levels of control and Rbpj iΔEC mice on HFD during 2‐DG uptake assay. n = 5, data represent mean ± SEM, unpaired t‐test.
  • I
    Plasma insulin levels of control and Rbpj iΔEC mice on HFD during 2‐DG uptake assay. n = 5, data represent mean ± SEM, unpaired t‐test.
  • J
    2‐DG uptake levels in skeletal muscle of control (n = 5) and Rbpj iΔEC (n = 4) mice on HFD. Data represent mean ± SEM, unpaired t‐test.
  • K
    2‐DG uptake levels in vWAT of control and Rbpj iΔEC mice. n = 4, data represent mean ± SEM, unpaired t‐test.