Table 1.
Recognition of antithrombin in plasma by sdAbs
| Human | Simian | Mouse | Rat | Rabbit | Canine | Bovine | Porcine | |
|---|---|---|---|---|---|---|---|---|
| KB‐AT‐01 | ++ | ++ | ++ | + | + | − | − | − |
| KB‐AT‐02 | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ |
| KB‐AT‐03 | ++ | ++ | ++ | + | − | + | − | − |
| KB‐AT‐04 | + | + | ++ | + | − | + | − | + |
| KB‐AT‐05 | + | + | ++ | − | − | − | − | − |
| KB‐AT‐06 | ++ | ++ | + | + | ++ | + | − | + |
| KB‐AT‐07 | ++ | ++ | + | − | − | − | − | − |
| Positive cntl | ++ | ++ | ++ | ++ | + | ++ | + | ++ |
| Negative cntl | − | − | − | − | − | − | − | − |
Antibodies immobilized at 10 μg/ml, and plasmas diluted fourfold; Positive cntl: positive control, polyclonal anti‐antithrombin antibodies (Affinity Biologicals). Negative cntl: no antibody immobilized. Symbols represent the following: Negative binding defined as OD being ≤ 0.1; +: Moderate positive binding defined as OD being > 0.1 − < 0.5; ++: Strongly positive binding defined as OD being ≥ 0.5.