Table 2.
Thrombin generation test in human FVIII‐deficient plasma
| Added component in FVIII‐deficient plasma | N | ETP (μM•min) | Thrombin Peak (nM) | Lag time (min) | Time to Peak (min) |
|---|---|---|---|---|---|
| FVIII (1 U/ml) | 4 | 1.7 ± 0.1 | 262 ± 23 | 2.8 ± 0.3 | 4 ± 1 |
| FVIII (0.1 U/ml) | 3 | 1.3 ± 0.1 | 163 ± 14 | 3.3 ± 1.2 | 7 ± 2 |
| FVIII (0.025 U/ml) | 3 | 1.0 ± 0.1 | 106 ± 11 | 3.4 ± 1.4 | 11 ± 3 |
| None | 5 | 0.3 ± 0.1 | 30 ± 3 | 5.8 ± 1.9 | 15 ± 5 |
| KB‐AT‐0203 (3.3 μM) | 3 | 2.7 ± 0.5 | 185 ± 11 | 3.3 ± 0.6 | 9 ± 3 |
| KB‐AT‐0203 (6.6 μM) | 3 | 3.6 ± 0.7 | 225 ± 23 | 3.8 ± 0.7 | 8 ± 2 |
| Normal plasma | 6 | 1.5 ± 0.1 | 310 ± 5 | 3.0 ± 0.3 | 5 ± 1 |
Parameters for measuring thrombin generation (ETP, thrombin peak, lag time, and time to peak) were measured in immune‐depleted FVIII‐deficient human plasma in the presence of tissue factor (1 pM) and phospholipids (4 μM) with or without FVIII, or with KB‐AT‐23. Data are presented as mean ± SD.