Table 3.
Thrombin generation test in murine FVIII‐deficient plasma
| Added component in FVIII‐deficient plasma | N | ETP (μM•min) | Thrombin Peak (nM) | Lag time (min) | Time to Peak (min) |
|---|---|---|---|---|---|
| None | 4 | 0.3 ± 0.1 | 35 ± 11 | 0.8 ± 0.3 | 3.3 ± 0.3 |
| KB‐AT‐23 (2 μM) | 4 | 0.9 ± 0.1 | 121 ± 7 | 0.8 ± 0.2 | 2.6 ± 0.2 |
| KB‐AT‐23 (2 μM) + Anti‐FVIII (8 BU/ml) | 4 | 0.9 ± 0.1 | 111 ± 6 | 0.5 ± 0.2 | 2.0 ± 0.1 |
| KB‐AT‐23 (2 μM) + Antithrombin (2 μM) | 4 | 0.2 ± 0.1 | 31 ± 3 | 0.6 ± 0.2 | 2.7 ± 0.3 |
| Wild‐type plasma | 3 | 1.1 ± 0.1 | 147 ± 9 | 0.9 ± 0.2 | 2.6 ± 0.2 |
Parameters for measuring thrombin generation (ETP, thrombin peak, lag time, and time to peak) were measured in murine FVIII‐deficient human plasma in the presence of tissue factor (0.75 pM) and phospholipids (4 μM). Data are presented as mean ± SD.