Table 2.
Univariate and multivariate analysis of the effect of gender on survival outcome in LSCC
| Cancer-specific Survival S | Overall Survival | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
|
|
|
|
|
|||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender | ||||||||
| Female | Reference | Reference | Reference | Reference | ||||
| Male | 1.19 (1.14-1.25) | < 0.001 | 1.20 (1.16-1.25) | < 0.001 | 1.15 (1.11-1.19) | < 0.001 | 1.16 (1.12-1.20) | < 0.001 |
| Year of diagnosis | ||||||||
| 1973-1982 | Reference | Reference | Reference | Reference | ||||
| 1983-1992 | 1.04 (0.99-1.09) | 0.156 | 1.05 (1.00-1.10) | 0.051 | 1.10 (1.04-1.16) | 0.001 | 1.02 (0.97-1.08) | 0.440 |
| 1993-2002 | 1.14 (1.09-1.19) | < 0.001 | 1.15 (1.10-1.20) | < 0.001 | 1.18 (1.12-1.25) | < 0.001 | 1.13 (1.07-1.19) | < 0.001 |
| 2003-2014 | 1.18 (1.13-1.24) | < 0.001 | 1.16 (1.11-1.22) | < 0.001 | 1.19 (1.13-1.26) | < 0.001 | 1.12 (1.06-1.19) | < 0.001 |
| Age at diagnosis | ||||||||
| ≤ 60 years | Reference | Reference | Reference | Reference | ||||
| > 60 years | 1.31 (1.27-1.35) | < 0.001 | 1.46 (1.42-1.51) | < 0.001 | 1.79 (1.73-1.86) | < 0.001 | 1.91 (1.84-1.99) | < 0.001 |
| Race | ||||||||
| White | Reference | Reference | Reference | Reference | ||||
| Black | 1.04 (1.00-1.09) | 0.65 | 0.97 (0.93-1.02) | 0.213 | 1.03 (0.98-1.09) | 0.190 | 0.97 (0.92-1.02) | 0.195 |
| Others | 1.06 (0.98-1.16) | 0.144 | 1.02 (0.94-1.11) | 0.680 | 1.00 (0.91-1.10) | 0.961 | 0.98 (0.89-1.08) | 0.643 |
| Unknown | 1.31 (1.05-1.63) | 0.016 | 1.08 (0.87-1.35) | 0.491 | 1.26 (1.01-1.58) | 0.044 | 0.98 (0.84-1.32) | 0.63 |
| Marital status | ||||||||
| Married | Reference | Reference | Reference | Reference | ||||
| Unmarried | 1.14 (1.10-1.17) | < 0.001 | 1.02 (0.99-1.05) | 0.190 | 1.09 (1.05-1.13) | < 0.001 | 1.02 (0.99-1.06) | 0.243 |
| Unknown | 1.16 (1.08-1.25) | < 0.001 | 1.04 (0.97-1.11) | 0.307 | 1.11 (1.03-1.21) | 0.010 | 1.05 (0.97-1.14) | 0.214 |
| Site | ||||||||
| Supraglottis | Reference | Reference | Reference | Reference | ||||
| Glottis | 0.37 (0.46-0.38) | < 0.001 | 0.35 (0.34-0.36) | < 0.001 | 0.52 (0.50-0.55) | < 0.001 | 0.49 (0.47-0.51) | < 0.001 |
| Subglottis | 1.02 (0.91-1.15) | 0.726 | 0.97 (0.86-1.10) | 0.645 | 1.00 (0.87-1.17) | 0.954 | 0.93 (0.79-1.08) | 0.322 |
| Others | 1.17 (1.12-1.22) | < 0.001 | 1.21 (1.15-1.27) | < 0.001 | 1.13 (1.07-1.19) | < 0.001 | 1.15 (1.08-1.22) | < 0.001 |
| Grade | ||||||||
| Well differentiated | Reference | Reference | Reference | Reference | ||||
| Moderately differentiated | 0.95 (0.91-0.99) | 0.022 | 1.07 (1.02-1.11) | 0.006 | 0.99 (0.94-1.04) | 0.681 | 1.01 (0.96-1.06) | 0.698 |
| Poorly differentiated | 0.90 (0.85-0.94) | < 0.001 | 1.01 (0.96-1.07) | 0.642 | 0.95 (0.89-1.00) | 0.070 | 1.00 (0.94-1.06) | 0.860 |
| Undifferentiated | 0.61 (0.49-0.77) | < 0.001 | 0.80 (0.63-1.00) | 0.051 | 0.82 (0.62-1.08) | 0.162 | 0.82 (0.62-1.08) | 0.148 |
| Unknown | 0.87 (0.83-0.91) | < 0.001 | 0.96 (0.91-1.01) | 0.084 | 0.93 (0.88-0.99) | 0.013 | 0.96 (0.91-1.02) | 0.202 |