Table 3.

Subgroup analysis of the effect of gender on survival outcome in LSCC

Subgroup	Cancer-specific Survival		Overall Survival
	aHR	P-value	aHR	P-value
Year of diagnosis
1973-1982	1.25 (1.11-1.41)	< 0.001	1.23 (1.13-1.33)	< 0.001
1983-1992	1.14 (1.02-1.26)	0.017	1.12 (1.04-1.21)	0.003
1993-2002	1.17 (1.08-1.28)	< 0.001	1.09 (1.03-1.17)	0.006
2003-2014	1.21 (1.12-1.31)	< 0.001	1.18 (1.11-1.26)	< 0.001
Age at diagnosis
≤ 60 years	1.32 (1.23-1.43)	< 0.001	1.27 (1.20-1.35)	< 0.001
> 60 years	1.11 (1.04-1.18)	0.001	1.07 (1.03-1.12)	0.001
Race
White	1.21 (1.15-1.27)	< 0.001	1.15 (1.11-1.20)	< 0.001
Black	1.11 (0.98-1.25)	0.094	1.12 (1.03-1.23)	0.012
Others	1.25 (0.97-1.60)	0.084	1.18 (0.98-1.43)	0.085
Unknown	1.06 (0.61-1.85)	0.829	1.21 (0.77-1.90)	0.416
Marital status
Married	1.18 (1.11-1.26)	< 0.001	1.14 (1.09-1.20)	< 0.001
Unmarried	1.20 (1.12-1.29)	< 0.001	1.17 (1.11-1.24)	< 0.001
Unknown	1.23 (1.01-1.52)	0.045	1.07 (0.92-1.25)	0.383
Site
Supraglottis	1.25 (1.18-1.33)	< 0.001	1.20 (1.14-1.26)	< 0.001
Glottis	1.11 (1.01-1.23)	0.040	1.12 (1.05-1.19)	< 0.001
Subglottis	0.86 (0.60-1.25)	0.432	0.85 (0.63-1.14)	0.278
Others	1.26 (1.11-1.42)	< 0.001	1.17 (1.06-1.30)	0.002
Grade
Well differentiated	1.18 (1.05-1.32)	0.004	1.17 (1.08-1.27)	< 0.001
Moderately differentiated	1.23 (1.15-1.32)	< 0.001	1.19 (1.13-1.25)	< 0.001
Poorly differentiated	1.15 (1.03-1.29)	0.013	1.11 (1.02-1.20)	0.017
Undifferentiated	2.04 (0.88-4.74)	0.098	2.02 (1.15-3.57)	0.015
Unknown	1.16 (1.04-1.28)	0.006	1.09 (1.01-1.18)	0.023

aHR, adjusted hazard ratio; CI, confidence interval.