Protein expressions of apoptosis, fibrosis and DNA-damaged marker in urinary bladder by day 60 after CC induction. A. Protein expressions of cleaved caspase 3 (c-Csp3), * vs. other groups with different symbols (†, ‡), P < 0.0001. B. Protein expression of cleaved poly (ADP-ribose) polymerase (c-PARP), * vs. other groups with different symbols (†, ‡), P < 0.0001. C. Protein expression of transforming growth factor (TGF)-β, * vs. other groups with different symbols (†, ‡), P = 0.002. D. Protein expression of phosphorylated (p)-Smad3, * vs. other groups with different symbols (†, ‡), P < 0.0001. E. Protein expression of γ-H2AX, * vs. other groups with different symbols (†, ‡), P < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡) indicate significance at the 0.05 level. NC = normal control; CC = chronic cystitis; ECSW = extracorporeal shock wave.