Protein expressions of up- and down-stream inflammatory signaling in urinary bladder by day 60 after CC induction. A. Protein expression of toll-like receptor (TLR)-4, * vs. other groups with different symbols (†, ‡), P < 0.0001. B. Protein expression of myeloid differentiation primary response 88 (MYD88), * vs. other groups with different symbols (†, ‡), P < 0.0001. C. Protein expression of Mal, * vs. other groups with different symbols (†, ‡), P < 0.0001. D. Protein expression of tumor necrosis factor (TNF) receptor associated factor (TRAF), * vs. other groups with different symbols (†, ‡), P < 0.001. E. Protein expression of phosphorylated (p)-IκBα, * vs. other groups with different symbols (†, ‡), P < 0.0001. F. Protein expression of p-NF-κB, * vs. other groups with different symbols (†, ‡), P < 0.0001. G. Protein expression of TNF-α, * vs. other groups with different symbols (†, ‡), P < 0.0001. H. Protein expression of matrix metalloproteinase (MMP)-9, * vs. other groups with different symbols (†, ‡), P < 0.0001. I. Protein expression of COX-2, * vs. other groups with different symbols (†, ‡), P < 0.0001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡) indicate significance at the 0.05 level. NC = normal control; CC = chronic cystitis; ECSW = extracorporeal shock wave.