Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 6;20:281. doi: 10.1186/s12885-020-06788-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Representative images of the common immunohistochemical staining patterns for Shank2, cortactin and cyclin D1. a shows Shank2 staining (40x magnification) in non-neoplastic oesophageal squamous mucosa, cytoplasmic signal was observed in basal cells, which disappeared towards the luminal surface. b shows staining of CCND1 in non-neoplastic oesophageal squamous mucosa (40x magnification), staining was observed in nuclei, which disappeared towards the luminal surface. Panel A: Case UROC48 with co-amplification of the SHANK2, CTTN and CCND1 genes. a) shows intense cytoplasmic staining for Shank2 (score 3). b) intense cytoplasmic and membranous staining for cortactin (score 3). c) Moderate staining for cyclin D1 (score 1). Panel B: Case UROC144 with amplification of the SHANK2 gene only. a) shows intense cytoplasmic staining for Shank2 (score 3), b) shows intense cytoplasmic staining for cortactin (score 3) and c) shows moderate staining for cyclin D1 (score 2)