Table 1.
Focal gains identified by GISTIC 2.0 analysis (regions with ≤3 genes). Regions are ordered by chromosome
| Cytoband | q value | Peak boundaries | Approximate Size (kb) | Frequency (n = 51) (%) | Genes |
|---|---|---|---|---|---|
| 1q31.1 | 2.3726e-05 | chr1:185468920–185,520,599 | 51,679 | 10 (19.6) | PLA2G4A |
| 1p31.3 | 0.00062772 | chr1:66762738–66,812,099 | 49,361 | 7 (13.7) | SGIP1 |
| 2p24.2 | 0.0036518 | chr2:17635668–17,792,214 | 156,546 | 8 (15.7) | VSNL1, SMC6 |
| 2q24.3 | 0.010142 | chr2:165491226–165,903,111 | 411,885 | 5 (9.8) | SCN2A, SCN3A, SLC38A11 |
| 3q28 | 1.9145e-14 | chr3:190233839–190,297,244 | 63,405 | 21 (41.2) | TPRG1 |
| 4q13.3 | 0.0063346 | chr4:74554931–74,770,220 | 215,289 | 6 (11.8) | AFM, RASSF6 |
| 5p13.2 | 0.12506 | chr5:36212218–36,345,590 | 133,372 | 8 (15.7) | SKP2, C5orf33, RANBP3L |
| 6p24.3 | 0.10455 | chr6:7469233–7,587,193 | 117,96 | 4 (7.8) | DSP, C6orf151 |
| 7p11.2 | 0.039529 | chr7:54888060–55,205,929 | 317,869 | 5 (9.8) | EGFR |
| 8p12 | 0.072453 | chr8:36981731–37,716,301 | 734,57 | 6 (11.7) | ERLIN2, ZNF703 |
| 8p23.2 | 0.05569 | chr8:4993944–5,001,641 | 7697 | 7 (13.7) | CSMD1 |
| 8q24.12 | 3.026e-06 | chr8:122208528–122,239,169 | 30,641 | 18 (35.3) | SNTB1 |
| 8q24.21 | 4.72e-06 | chr8:128624619–128,707,294 | 82,675 | 17 (33) | MYC |
| 9p21.1 | 0.082133 | chr9:31568898–31,803,849 | 234,951 | 3 (5.9) | ACO1 |
| 10p11.21 | 0.080762 | chr10:35074847–35,469,974 | 395,127 | 3 (5.9) | CREM, CUL2, PARD3 |
| 11q13.3 | 2.782e-25 | chr11:69889604–70,002,885 | 113,281 | 19 (37.3) | CTTN, PPFIA1, SHANK2 |
| 12q14.1 | 0.00019309 | chr12:59418827–59,513,190 | 94,363 | 8 (15.7) | FAM19A2 |
| 13q22.1 | 3.1551e-09 | chr13:73904231–74,055,232 | 151,001 | 13 (25.5) | KLF12 |
| 14q23.2 | 0.080762 | chr14:61922478–62,321,423 | 398,945 | 6 (11.8) | KCNH5 |
| 15q11.2 | 5.1116e-09 | chr15:22380933–22,441,820 | 60,887 | 11 (21.6) | C15orf2 |
| 19q12 | 0.17889 | chr19:30530936–30,776,391 | 245,455 | 5 (9.8) | [UQCRFS1] |
| 20p12.2 | 0.14276 | chr20:10451892–11,654,335 | 1202,443 | 9 (17.6) | JAG1, C20orf94 |
| 20q13.2 | 0.15938 | chr20:52721957–52,854,653 | 132,696 | 7 (13.7) | DOK5 |