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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Matrix Biol. 2019 Oct 23;85-86:47–67. doi: 10.1016/j.matbio.2019.10.001

Figure 5.

Figure 5

Impact of collagen III reduction on the nanostructure of collagen fibrils in the PCM and T/IT-ECM of articular cartilage. a) Representative TEM images of collagen fibril structure on the sagittal sections of 2- month-old wild-type (+/+) and Col3a1+/– (+/−) cartilage PCM and T/IT-ECM. b) Histogram of fibril diameter distribution (> 130 fibrils from n = 4 animals for each genotype in each region). Shown together were the normal distribution, N (μ, σ2), fits to fibril diameters (for each fit, values of μ and σ correspond to the mean and standard deviation of fibril diameters shown in Table 2). c) Comparison of fibril diameter heterogeneity (variance) between the two genotypes (mean ± 95% CI, > 130 fibrils, n = 4).