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. 2020 Apr 7;13:20. doi: 10.1186/s13072-020-00341-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — a Overview of potential primary miRNAs predicted by EPIGENE in HepG2. b Example of an EPIGENE-predicted TU overlapping a microRNA cluster in HepG2 cell line. This region is located between lincRNA RP11-738B7.1 and gene NRF1. The TU shows an enrichment of H3K27ac and H3K4me3 at TSS (tracks shown in light violet), H3K36me3 in gene body (tracks shown in green), enhancer mark H3K4me1 few bps upstream and downstream of TSS (tracks shown in pink), GRO-seq in TSS (tracks shown in brown) and RNA Polymerase II ChIP-seq in TSS (tracks shown in blue). The predictions also show an absence of repression marks H3K27me3 and H3K9me3 (tracks shown in black) and RNA-seq evidence (tracks shown in dark pink)