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. 2020 Apr 7;19:86. doi: 10.1186/s12934-020-01342-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Summary of the PHA research achievements in Haloarchaea and Halophilic bacteria. Halophiles with strong PHA-accumulation ability are mined from various hypersaline habitats. PHA production cost is closely related with substrate usage, fermentation process, and PHA recovery. Halophiles are able to utilize a wide-range of low-cost substrates. PHA recovery from halophiles can be easily done by cell lysis using tap-water. The physicochemical parameters and fermentation modes have been optimized to enhance PHA production in halophiles. With the aim of genome sequencing technology and genetic manipulation tools, various PHA related genes, enzymes and pathways have been identified. With the help of advanced metabolic engineering tools and strategies, more efficient microbial cell factory has been developed for PHA production using halophiles