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. 2020 Apr 6;21:90. doi: 10.1186/s13059-020-01982-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — RBP co-association predicts known and novel RNP complexes. a Heatmap indicates the pairwise fraction of eCLIP peaks overlapping between datasets. Callout examples are shown for known complexes, RBP families, same RBP profiled across cell types, and putative novel complexes. b GSEA analysis comparing the fraction overlap observed profiling the same RBP in both K562 and HepG2, compared against random pairings of RBPs (with one profiled in K562 and the other in HepG2). c As in b, but using the set of RBPs with interactions reported in the BioPlex IP-mass spectrometry database [52]