Table 1.
Characteristics of elderly and non-elderly NAFLD patients were compared using1:3 sex-matched analysis
| Characteristics | Elderly NAFLD patients | Non-elderly NAFLD patients | P value |
|---|---|---|---|
| median (IQR); n (%) | (n = 175) | (n = 525) | |
| Age (year) | 64 (62–67) | 46 (36–54) | < 0.001 |
| Female | 102 (58.3%) | 306 (58.3%) | 1 |
| Weight (kg) | 69.45 (62.08–78.13) | 78.5 (68.1–97.3) | < 0.001 |
| Height (m) | 1.6 (1.54–1.67) | 1.6 (1.6–1.7) | < 0.001 |
| BMI (kg/m2) | 27.19 (24.73–30.34) | 29.62 (26.45–35) | < 0.001 |
| BMI ≥ 25 (kg/m2) | 126 (72%) | 443 (84.4%) | < 0.001 |
| Waist circumference (cm) | 92.05 (81.75–99.63) | 91.2 (78–102.5) | 0.813 |
| Hip circumference (cm) | 97 (87.75–104) | 100 (88–108) | 0.037 |
| Central obesity | 126 (85.1%) | 350 (85.6%) | 0.987 |
| Diabetes | 122 (69.7%) | 237 (45.1%) | < 0.001 |
| Hypertension | 122 (74.8%) | 189 (43.8%) | < 0.001 |
| Dyslipidemia | 148 (84.6%) | 374 (71.2%) | < 0.001 |
| Albumin (g/L) | 43 (41–46) | 44 (41–46) | 0.177 |
| ALT (U/L) | 55 (38–94) | 61 (37–90) | 0.002 |
| AST (U/L) | 43 (26–66) | 40 (29.8–68) | 0.327 |
| ALP (U/L) | 69 (53.25–91) | 67 (48.5–91.5) | 0.942 |
| GGT (U/L) | 53 (37–87) | 50 (31–86) | 0.198 |
| HbA1c (%) | 6.65 (5.9–7.33) | 6.1 (5.6–7.2) | < 0.001 |
| Total cholesterol (mmol/L) | 4.4 (3.5–5.33) | 5 (4.3–5.7) | < 0.001 |
| LDL cholesterol (mmol/L) | 2.3 (1.79–3.25) | 3 (2.43–3.7) | < 0.001 |
| HDL cholesterol (mmol/L) | 1.25 (1.1–1.44) | 1.2 (1.01–1.5) | 0.248 |
| Triglycerides (mmol/L) | 1.4 (1.1–1.8) | 1.4 (1.1–1.9) | 0.509 |
| Hemoglobin (g/dL) | 14.1 (13.4–15.08) | 13.9 (13.1–15.1) | 0.775 |
| Platelet (109/L) | 227.5 (177.5–280.75) | 251 (202–297) | < 0.001 |
| WBC (109/L) | 6.57 (5.6–8) | 7.3 (5.9–8.8) | 0.015 |
| NAFLD Activity Score (NAS) | 4 (3–5) | 4 (3–5) | 0.332 |
| NAS ≥ 5 | 58 (33.1%) | 221 (40.2%) | 0.097 |
| NASH | 118 (67.4%) | 335 (63.8%) | 0.386 |
| Significant fibrosis (≥F2): histopathology | 86 (49.1%) | 138 (26.3%) | < 0.001 |
| Advanced fibrosis (≥F3): histopathology | 62 (35.4%) | 70 (13.3%) | < 0.001 |
| Cirrhosis | 27 (15.4%) | 25 (4.8%) | < 0.001 |
| NAFLD fibrosis score (NFS)a | −0.75 (1.49) | −1.91 (1.88) | < 0.001 |
| APRI scorea | 1.18 (2.02) | 0.74 (1.55) | 0.02 |
| FIB-4 scorea | 3.88 (6.72) | 1.58 (3.93) | < 0.001 |
APRI AST to platelet ratio index, BMI body mass index; Non-Alcoholic Steatohepatitis (NAS) score, amean (SD)