Table 2.
Characteristics of elderly groups with advanced fibrosis (F3–4) vs. non-advanced fibrosis (F0–2)
| Elderly NAFLD | Non-advanced fibrosis | Advanced fibrosis | P-value |
|---|---|---|---|
| Characteristics, median (IQR); n (%) | (n = 113) | (n = 62) | |
| Age (year) | 64 (62–66) | 65 (62–68) | 0.118 |
| Female | 57 (50.4%) | 45 (72.6%) | 0.005 |
| Weight (kg) | 68.35 (59.88–78.00) | 70.7 (64–79) | 0.565 |
| Height (m) | 1.6 (1.57–1.70) | 1.6 (1.54–1.68) | 0.227 |
| BMI (kg/m2) | 26.68 (23.94–29.12) | 27.55 (25.89–31.22) | 0.055 |
| BMI ≥ 25 (kg/m2) | 74 (65.5%) | 52 (83.9%) | 0.01 |
| Waist circumference (cm) | 92.05 (84–100) | 96 (89.50–102.50) | 0.017 |
| Hip circumference (cm) | 98 (92.00–104.63) | 101 (95.50–109) | 0.158 |
| Central obesity | 72 (79.1%) | 54 (94.7%) | 0.009 |
| Diabetes | 73 (64.6%) | 49 (79.0%) | 0.047 |
| Hypertension | 69 (67%) | 53 (88.3%) | 0.002 |
| Dyslipidemia | 94 (83.2%) | 54 (87.1%) | 0.493 |
| Albumin (g/L) | 43 (42–45) | 43 (40–46) | 0.637 |
| ALT (U/L) | 52.5 (37–89.75) | 66 (36–91) | 0.276 |
| AST (U/L) | 38.5 (27.25–56.75) | 51 (34–82) | 0.086 |
| ALP (U/L) | 63 (49–117.25) | 69.5 (69–70) | 0.615 |
| GGT (U/L) | 48 (34.25–70.75) | 75 (42.75–122.5) | 0.002 |
| HbA1c (%) | 6.5 (5.9–7.4) | 6.7 (6.13–7.28) | 0.435 |
| Total cholesterol (mmol/L) | 4.4 (3.5–5.38) | 4.35 (3.53–5.1) | 0.483 |
| LDL cholesterol (mmol/L) | 2.32 (1.8–3.23) | 2.23 (1.7–3.08) | 0.389 |
| HDL cholesterol (mmol/L) | 1.2 (1.03–1.4) | 1.3 (1.1–1.5) | 0.068 |
| Triglycerides (mmol/L) | 1.4 (1.2–1.79) | 1.5 (1.13–1.8) | 0.833 |
| Hemoglobin (g/dL) | 14.1 (13.4–14.8) | 13.45 (12.63–14.68) | 0.055 |
| Platelet (109/L) | 229.5 (193–284.25) | 205 (145.75–243.25) | 0.003 |
| WBC (109/L) | 7 (5.8–8.23) | 6.9 (5.83–8.15) | 0.638 |
| NAFLD Activity Score (NAS) | 4 (3–5) | 4 (4–5) | 0.023 |
| NAS ≥ 5 | 32 (28.3%) | 26 (41.9%) | 0.067 |
| Platelet count < 140 × 109/L | 10 (8.8%) | 13 (21%) | 0.023 |
| NAFL fibrosis score (NFS)a | −1.00 (1.48) | −0.24 (1.4) | 0.005 |
| APRI scorea | 0.91 (1.41) | 1.74 (2.85) | 0.077 |
| FIB-4 scorea | 3.06 (5.15) | 5.57 (9.01) | 0.095 |
APRI AST to platelet ratio index, BMI body mass index; Non-Alcoholic Steatohepatitis (NAS) score
amean (SD)