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. 2020 Apr 6;12:53. doi: 10.1186/s13148-020-00843-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Differentially methylated position analysis in adipose-derived stem cells isolated from patients with Crohn’s disease and healthy controls. a Intragenic differentially methylated position (DMP) distribution: approximately 45% of the DMPs are located in the gene body and 35% are located in the promoter. CpG allocation: > 50% of the CpGs are in the open sea region. b Distribution of hypo- and hypermethylated DMPs for Crohn’s-hASC and control-hASCs. c Heatmap and hierarchical clustering of CpGs according to their methylation profile in Crohn’s disease patients compared with healthy donors. Red bars represent hypomethylated positions and yellow bars hypermethylated positions. d Principal component analysis demonstrating the first two main components of the significant CpG data set. e Manhattan plot of all DMPs. Significant DMPs are colored in green, achieving the significance threshold (p < 0.0001). f Volcano plot showing the top DMPs associated with genes. Visualization of the genes with the highest number of significant CpGs. Negative values (points to the left of the graph) indicate hypomethylated; positive values (points to the right of the graph) indicate hypermethylated. ExonBnd, exon boundaries; UTR, untranslated region; TSS, transcription start site; hASCs, human adipose-stem cells