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. 2020 Apr 7;18:159. doi: 10.1186/s12967-020-02318-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — a Murine CH12F3 cells were subjected to HDACi treatment at the given concentrations for 48 h prior to western analysis of UNG1/2 expression. b Representative flow cytograms illustrating dose-dependent reduction in IgM to IgA class switching in CH12F3 cells with induction treatment and addition of HDACi as indicated. c Quantification of genomic uracil in HEK293, HeLa, Jurkat and SUDHL5 cells after 48 h treatment with 2 µM SAHA or 5 µM MS-275 for 48 h. Red dashed line indicates dU level in UNG-treated DNA control (detection limit)