Fig. 2.

Principal component 2 (PC2) and 3 (PC3) scores from principal component analysis (PCA) of interferon-regulated gene (IRG) scores from JDM patients with other conditions. a PCA-A with JDM (including JDM highest quartile IRG score, JDM-HQ), CANDLE, SAVI, NOMID, and HC. b PCA-B with anti-MDA5 autoantibody-positive subgroup of JDM, CANDLE, SAVI, NOMID, and HC. c PCA-C with anti-NXP2 autoantibody-positive subgroup of JDM, CANDLE, SAVI, NOMID, and HC. d PCA-D with anti-TIF1 autoantibody-positive subgroup of JDM, CANDLE, SAVI, NOMID, and HC. Dotted circles represent each group, including CANDLE (pink), SAVI (red), and JDM-HQ or JDM myositis-specific autoantibody (MSA) group (anti-TIF1, anti-NXP2, anti-MDA5) (blue). JDM, as opposed to JDM-HQ, in a represents the lower 3 quartiles of JDM IRG scores. Abbreviations: IRG, interferon-regulated gene; JDM, juvenile dermatomyositis; JDM-HQ, highest-quartile scores in JDM; TIF1, subgroup of JDM with anti-TIF1 myositis-specific autoantibodies; NXP2, subgroup of JDM with anti-NXP2 myositis-specific autoantibodies; MDA5, subgroup of JDM with anti-MDA5 myositis-specific autoantibodies; neg, subgroup of JDM that was negative on testing for myositis-specific autoantibodies; CANDLE, Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated temperature; SAVI, STING-Associated Vasculopathy with onset during Infancy; NOMID, neonatal-onset multisystem inflammatory disease; HC, healthy controls